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Nzymes Ox-E Drops — daily wellness, on-the-spot relief, for pets of all ages
Top seller Daily wellness

Ox-E Drops

4.6 ★★★★½ 312 verified reviews

Support for pH balance and immunity — plus on-the-spot relief when life calls for it.

A few drops in the bowl each day support your pet's immune function and natural pH balance — and the same bottle, diluted, becomes an on-the-spot rinse for skin, ears, and eyes.

SizeSame formula · same drops
Purchase type
Ships every
QuantityPer-bottle savings stack
1 bottle × $29.99$29.99
Order total$29.99
$35.01 more to unlock free shipping

120 Day Worry-Free Guarantee

GMO-free
Clean, simple formula
100% human-grade
Safe for pets and people
Concentrated
A few drops per use
Made in U.S.A.
Family-owned since 1999
1M+ pets & people
Trusted since 1999
120 Day
Worry-Free Guarantee
The daily challenge

Every day, your pet’s body is
working to stay well.

Toxins in the food, water, and air. Stress. Yeast and other invaders always looking for an opening. A body in balance holds them off without you ever noticing.

But when it falls behind, you start to see it: the itch that won’t quit, the gunky ears, the flare-ups that keep coming back.

Give the body what it needs to rebalance, and those signals quiet down. Less scratching, clearer ears, and a pet who simply feels more like themselves again.

Steady energyday after day
The pep that returns. When the body isn’t fighting an uphill battle, owners often notice steadier energy and a pet that acts younger than its years.
pH 13naturally alkaline
The invisible workload. An alkaline, oxygen-rich formula helps the body keep unwanted microbes from getting comfortable.
2 jobsone little bottle
Inside and out. Drops in the bowl for daily wellness; diluted on skin, ears, and eyes when life calls for it.
In their own words

Why Owners Reach for It

We let the results speak for themselves. These are the uses that come up again and again across verified Ox-E Drops reviews, starting with the one we hear about most.

4.6★
Average rating
87%
Rated 4 or 5 stars
312
Verified reviews
Most-mentioned use

Calmer, less-itchy skin is why owners reach for Ox-E Drops most.

“Helped my black lab Preston stop scratching. I just had him groomed and the groomer commented how beautiful his coat is now.” · Kathy L., verified review

Calmer, less-itchy skin and coat

"This has really helped with Josie's allergies. She has been taking it for 2 years now and is much better."Christy S. · Verified review

On-the-spot relief, diluted

"Used it mostly topically for my dog. The only thing that was stopping his hot spots from spreading. Thank you!"Nailia G. · Verified review

Yeast kept in check

"Started Ox-E for our dog's chronic yeast issues. Great improvement in only a week."John H. · Verified review

Everyday immune strength

"A must to use every day to keep my dogs' immune systems strong."Rachel M. · Verified review

Warts and papillomas

"Used as directed to treat my dog's canine papillomas. They were gone in a week."Jennifer B. · Verified review

When owners tend to notice
First few daysDrops go in the bowl, and many owners report a little more pep and less scratching early on
1 to 2 weeksItchy skin, hot spots, and yeasty odors tend to ease with consistent daily use
On the shelfIt becomes the bottle owners keep on hand, for the bowl and for whatever turns up next

"These drops are amazing. I put it in food and water. It's a bonus in any skin program, making a big impact by helping circulation in the body and skin."Sheila B. · Verified review

Average rating and review count reflect this product's verified reviews. Bar lengths reflect how often each use is mentioned across verified reviews, not a guaranteed result. Quotes are individual experiences. Ox-E Drops is not intended to diagnose, treat, cure, or prevent any disease; every pet is different and individual results may vary.

A Nova Scotia Duck Tolling Retriever lying on a pebble beach by the ocean — the everyday wellness Ox-E Drops supports

Wellness in every drop.

The foods and fluids our pets consume each day can influence their pH balance. Just a few diluted drops can help support natural immune function, everyday vitality, digestion, and of course a healthy pH.

See how it works →
Inside the name and the bottle

Oxygen&Electrons

The name "Ox-E" comes from oxygen and electrons — the two parts of a stabilized oxidation reaction the body uses to support healthy immune function and keep its pH in balance, clearing what doesn't belong and protecting what does.

Ox — for oxygen
Cluster of clear dropper bottles — stabilized oxygen, the defender

Stabilized Oxygen · The defender

A stabilized oxygen complex the body releases on contact with cells, water, or surface tissue. Where it's needed, it works; where it's not, it passes through. Oxygen is what the immune system uses to clear what doesn't belong — pathogens, biofilms, the bad-breath layer in a water bowl — backing up healthy immune function day to day. At the stomach's natural pH, the formula briefly forms chlorine dioxide (not free chlorine), then returns to chlorite ions the body absorbs and clears through the kidneys. The "Ox" in Ox-E.

E — for electrons
Atomic model — free electrons, the body's antioxidant currency

Electrons · The protector

Free electrons — the body's own antioxidant currency. They neutralize free radicals, help keep pH in balance, and donate stability to cells under stress. The foods and fluids pets take in each day, modern diets, and chronic inflammation all drain the electron pool faster than the body can replace it. Inside the body, immune cells called leukocytes use the formula's chlorite as a substrate to boost peroxidase enzymes, part of how the immune system oxidizes and clears foreign material. The "E" in Ox-E.

1,200
drops in every 2 oz bottle
The format

Stabilized oxygen, in solution.

Ox-E Drops is a water-based concentrate of stabilized oxygen and free electrons — no oils, no alcohol, no flavor. Just 5% sodium chlorite and 95% reverse-osmosis water, naturally alkaline at pH 13. The body releases the oxygen where it's needed; healthy tissue passes through unbothered.

A few drops daily, in food or drinking water, is the daily wellness layer that supports healthy immune function and pH balance. Diluted to a 2% solution — 1 teaspoon Ox-E in 8 oz purified water — the same bottle becomes the topical rinse for hot spots, gunky ears, watery eyes, and skin-fold cleanliness. One bottle, endless uses — the way Nzymes families have always used it.

A bright-eyed dog at ease outdoors — the everyday balance Ox-E Drops supports

Balance the inside.
Watch the outside follow.

Digestion, immunity, energy: every system in your dog's body leans on the same quiet inner chemistry. Here's why a few drops a day make a difference.

Get the exact dose →
  1. 1

    Modern life tips the chemistry

    Processed diets, stress, and age quietly push the body's pH and oxygen balance off center.

  2. 2

    Every system leans harder

    Digestion, immunity, and energy all depend on that inner balance, and they work overtime when it drifts.

  3. 3

    Small troubles keep returning

    Flare-ups, low energy, and slow bounce-backs show up wherever your dog is most vulnerable.

  4. 4

    The chemistry comes back to center

    A few drops a day support healthy pH and oxygen balance from within, and the systems that lean on that quiet chemistry stop working overtime.

Inside and out

Two jobs, one bottle.

Daily wellness layer
Nzymes Ox-E Drops 2 oz dropper bottle

The 2 oz dropper bottle — a few drops in food or water for immune & pH balance, daily.

Internal use · daily

The daily-wellness layer.

A few drops daily, in the water bowl or on food, add stabilized oxygen to your pet's day. It helps balance pH and back up the immune system the body already has, and the body uses what it needs and clears the rest. The one rule: Ox-E is always diluted before it reaches your pet. In the water bowl, the water does that for you, so you just add the drops. On food, stir the drops into a teaspoon or two of water first, then pour it over the meal.

In food or drinking water, twice daily.

2–5drops Per dose · by weight

1 drop per 20 lb body weight, twice daily (2-drop minimum). Use the dose tool below for your pet's exact count.

Topical use · diluted

The on-the-spot rinse.

Always dilute before applying. Mix the drops with purified water in a separate clean container or spray bottle, then apply gently to the area as needed. The same 2 oz dropper bottle covers months of topical use — a few drops make a generous mix.

2%solution Per back-of-label

1 teaspoon Ox-E (about 80 drops) + 8 oz purified water.

Store in a clean 8 oz spray bottle for ease of use. Apply 3–4× daily or as needed. Do not use undiluted — at pH 13, the concentrate may stain fabric and irritate skin.

Nzymes Ox-E Mineral Mist — pre-diluted topical spray
Don't want to mix?

Try Ox-E Mineral Mist — the ready-to-spray version.

Pre-diluted Ox-E, fortified with zinc, copper, and colloidal silver. Same topical playbook — no measuring, no mixing, no spray bottle to keep clean. Built for the same skin, ear, and eye moments — just point and spray.

Learn about Mineral Mist →
Daily uses
Drinking water

Add your pet's drop count straight to the bowl at each refill. The water dilutes it for you, so there's no pre-mixing.

On food

Stir the drops into a teaspoon or two of water, then pour over the meal. No taste pets notice.

pH balance

Supports healthy alkalinity as a daily layer.

Immune backup

A daily drop of wellness the body uses to clear what doesn't belong. For extra support, move to 3× daily.

Topical uses
Hot spots & skin folds

Gentle mist on red, irritated patches between baths. Calms surface flora.

Gunky ears

Dab on a cotton pad and clean the outer ear. Don't flood the canal.

Watery eye corners

Wipe tear streaks with a damp cotton ball — gentle, not stinging.

Bowl & bedding rinse

Wipe-down for stainless bowls, soft toys, and clean-up jobs around the food area.

See it in action
In drinking water — add the daily drop count at refill. The lowest-friction way, great for travel.
On food — stir the drops into a teaspoon of water, then pour over the meal. Or syringe orally along the teeth-line.
2% topical — 1 tsp (about 80 drops) + 8 oz water in a spray bottle. Apply as needed; never undiluted.
Good to know
  • Find your rhythm. Internal use is twice daily; topical is as-needed, whenever a spot needs it.
  • Respiratory trick. Add 1 teaspoon of drops to a gallon vaporizer and let it run near your pet.
  • Tougher cases. For chronic skin, ear, or eye situations, book a consult before starting a new routine.
Always diluted. Never straight from the bottle.

Ox-E Drops is a full-strength concentrate, naturally alkaline at pH 13, so it is always used diluted before it reaches your pet. The good news: in the water bowl, the water does the diluting for you, so you just add the drops. On food, stir them into a teaspoon or two of water first; for skin, ears, and eyes, mix a 2% solution (1 tsp to 8 oz purified water) before applying. Used straight, the concentrate can irritate or burn. Want it pre-mixed and ready to spray? Shop Ox-E Mineral Mist.

Find your dose

How much for your pet?

Tell us about your pet: name, species, and weight. We'll show the daily drops (in food or water) and the right bottle to keep them stocked. Add more than one animal, or switch to horses and ponies, and we'll size it up.

Tell us about your dog

Let's get the dose right.

Species
Weight 40 lbs
2 drops twice daily
One 2 oz bottle lasts ~10 months

Auto-ship every 9 months keeps your dog stocked, and saves 10% on every order.

The Ox-E rhythm

What changes, and when.

Ox-E works in two timeframes. Topical use is almost-immediate — the kind of relief you can see by the next day. Internal use is the slow build — the daily-wellness effect that compounds week over week. Here's what most families notice.

Days 1 – 3

The topical reset

  • Hot spots and skin folds calm down — less redness, less licking
  • Gunky ears wipe cleaner; bowl water stays fresher
  • Watery eye corners stop staining as quickly
Weeks 2 – 4

The internal layer lands

  • Breath smells fresher (gut-and-mouth pH balance)
  • Recovery from environmental stress feels faster
  • Coat looks cleaner — fewer surface issues to chase
Month 2 onward

The daily-wellness habit

  • Ox-E becomes the bottle that lives on the counter — the one you reach for first when something needs a quick rinse
  • Drinking water stays fresh between bowl scrubs
  • For multi-pet families: one 2 oz bottle lasts most pets 6–12 months — the 8 oz refiller is a multi-year supply

For chronic skin, ear, or eye conditions — or pets on medications — book a consult before starting.
Ox-E Drops is not intended to diagnose, cure, treat, or prevent any disease.

Compare our liquids

Compare our liquid products.

Nzymes makes three liquid supplements and they don't overlap. Tracite Minerals is the amplifying layer — trace minerals that help everything else work harder. Black Leaf is the botanical defense layer. Ox-E Drops is the pH-and-cleanliness layer — daily oxygen for the inside, on-the-spot relief for the outside. Many households use two of the three; some use all three.

Nzymes paw & leaf logomarkThree liquids, three different jobs. Pick what your pet actually needs.
Nzymes Ox-E Drops 2 oz bottle
Ox-E Drops
Daily wellness · $29.99 · 2 oz
Nzymes Tincture of Black Leaf
Tincture of Black Leaf
Botanical defense · liquid · 2 oz
Nzymes Tracite Minerals
Tracite Minerals
Cellular renewal · liquid · 2 oz
What it is
Stabilized oxygen + electrons in a water-based solution — a long-trusted formula for daily wellness and on-the-spot relief.
A 5:1 herbal tincture of Black Walnut, Olive Leaf, and Cayenne. Plant alkaloids, suspended in 50% ethanol.
70+ trace minerals + 18 amino acids in pure fulvic colloidal suspension — the spark of life in every drop.
What it supports
pH balance
Oral & drinking-water cleanliness
Skin, ears & eyes (diluted topical)
Digestive resilience
Microbial & parasitic balance
Circulation
Cellular renewal
Bioelectric energy
Nutrient amplifier
Daily form factor
Drops to food or water; diluted for topical use on skin, ears, eyes.
2–20 drops, twice daily (by weight) — in food.
A few drops, twice daily — in food.
Internal / topical
Both. Daily in food or water; diluted on the surface as needed.
Internal. Hot-spot dab is a sometimes-tool, not a daily one.
Internal only.
Best for
Bad breath · gunky ears · skin folds · the day-to-day cleanliness layer.
Outdoor dogs · scavengers · multi-pet households · post-deworm support.
Pets on commercial diets · dull coats · senior pets · working dogs.

Need help deciding? Book a free 30-min consult — we'll point you to the right starting place.

Made for pets, made for people — because oxygen and electrons are how every body cleans itself, whether it walks on two legs or four.

Same formula
Nzymes Ox-E Drops for People 2 oz dropper bottle
Made for humans, too

Ox-E Drops for People

Same formula. Same drop count. Same shelf life. The pet version is the same solution in a pet-friendly bottle. Keep one on the counter and the whole household can use it.

View Ox-E for People →
Nzymes Ox-E Mineral Mist — pre-diluted topical spray with zinc, copper & colloidal silver
Topical · ready to spray

Ox-E Mineral Mist

Pre-diluted Ox-E with zinc, copper & colloidal silver added — the same topical playbook as a 2% solution, plus a mineral-boost layer for skin, ears, and eyes.

View Mineral Mist →
120day window
Risk-free trial

Our 120 Day Worry-Free Guarantee.

Try Ox-E Drops with your pet for four full months. If it isn't the right fit, return the unused portion for a full refund. No questions asked.

Try Ox-E →
Family owned and operated

Real people, real pets.

Nzymes began in 1999, started by our own family after we went looking for real answers for a dog of our own. Back then, almost no one was talking about what nutrition could do for pets. We were, and that conviction still shapes every product we make.

More than 25 years later, we are still family owned and operated. The same family answers the phone, packs your order, and stays with you long after checkout. Not sure where to start? Our free consultations are open to everyone, for as long as your pet needs us.

Wag More. Worry Less.

FAQs

Common questions.

What it is

Ox-E Drops help restore healthy pH balance in your pet's body — an essential foundation for strong immunity, smooth digestion, and everyday vitality. By supporting alkalinity, these drops help the body naturally clear toxins and defend against unwanted invaders — inside and out.

They can also be diluted for topical use on the skin, eyes, or ears to soothe irritation and support natural recovery. This dual-action versatility — internal and topical from the same bottle — makes Ox-E a trusted essential in every pet household.

The name comes from their unique focus on Oxygen and Electrons ("Ox-E"). This stabilized oxygen formula creates an environment that supports cellular health, clears toxins, and makes it harder for harmful microbes to thrive.

In short, Ox-E Drops deliver oxygen-driven antioxidant protection in every drop — helping pets stay balanced inside and out.

It comes down to some simple chemistry. Ox-E is a stabilized solution of 5% sodium chlorite in reverse-osmosis water. At the stomach's natural pH, the chlorite briefly converts to chlorine dioxide (not free chlorine), then back to chlorite ions, which the body absorbs and clears through the kidneys.

Along the way, immune cells called leukocytes use that chlorite as a substrate to boost peroxidase enzymes, part of how the immune system oxidizes and clears foreign material. In plain terms, Ox-E gives your pet's own defenses a little more to work with, rather than adding something the body has to fight.

Ox-E Drops is the concentrate. Use it internally (a few drops in food or water, twice daily) or mix your own 2% solution (1 tsp + 8 oz water) for topical use.

Ox-E Mineral Mist is the pre-diluted topical sibling — Ox-E already mixed to the right strength, with zinc, copper, and colloidal silver added. Use it the same way you'd use a homemade 2% mix, just without measuring or storing it yourself.

Many families keep both: the Drops on the counter for daily internal use, the Mist in the bathroom for on-the-spot topical care.

Using it day to day

For internal use, give 1 drop of Ox-E per 20 lb of body weight, twice daily, with a 2-drop minimum for small pets. Dilute with a teaspoon of water and add to food, or give orally with a syringe along the teeth-line to prevent choking. You can also add the same count to your pet's water dish at refill — especially when traveling.

For topical use, mix 1 teaspoon Ox-E + 8 oz purified water in a clean spray bottle to make a 2% solution. Apply 3–4× daily to skin, ears, or eyes as needed. Always dilute — at pH 13, the concentrate may stain fabric and irritate skin if used straight.

For extra immune support, you can move internal use to 3× daily. Because Ox-E is concentrated, a little goes a long way.

Yes, and it's one of the most popular ways to use it. Add the same per-weight drop count to the water dish at refill time. Many families do this every day as part of their routine, and some like that it gives city or fluoridated tap water a cleaner starting point.

If your pet is a hesitant drinker, add the drops to food instead so you know the full dose went in. Keep the amount consistent day to day rather than doubling up.

Yes — that's the on-the-spot relief use case. Always dilute first: 1 teaspoon Ox-E + 8 oz purified water = a 2% solution. Apply 3–4× daily with a cotton ball, clean cloth, or fine-mist spray; don't flood the ear canal.

Important safety note: Ox-E concentrate is naturally alkaline at pH 13 and can stain fabric or irritate skin if used straight. Always dilute before any topical use, and if undiluted concentrate touches skin, rinse thoroughly with water.

For chronic or severe cases — long-standing hot spots, persistent ear gunk, eye conditions that won't clear — book a consult before starting a new topical routine.

Absolutely. Because Ox-E is dosed in drops and a little goes a long way, one bottle comfortably covers a multi-pet household. Dose each pet by weight — 1 drop per 20 lb, twice daily, with a 2-drop minimum for little ones.

For a shared water bowl, add up the counts for the pets who drink from it. Plenty of longtime customers run their whole pack on a single 2 oz or 8 oz bottle.

Yes. The label includes a bird dose: 1 drop in the bird's water dish daily. For dogs, cats, and other companion animals, follow the standard per-weight count, 1 drop per 20 lb twice daily with a 2-drop minimum, and dilute for any topical use.

Horses and ponies are dosed by weight too; the dose tool above switches to a horses and ponies mode. For an exotic or a very small animal, book a consult and we'll help you size it.

Because Ox-E is dosed in drops (twice daily) and a 2 oz bottle holds roughly 1,200 drops, even large dogs get many months from a single bottle:

Cat & small dog (under 20 lb): ~10 months per bottle.
Medium dog (20–60 lb): ~7–10 months per bottle.
Large dog (60–90 lb): ~6–8 months per bottle.
Extra-large + giant (100+ lb): ~4 months per bottle.

Fun fact: the 8 oz refiller holds about 5,400 drops, the same formula in a bigger, better-value bottle. Most one-pet households keep the refiller in the cupboard and top up the 2 oz dispensing bottle every few months.

No refrigeration needed. Store the concentrate at room temperature, out of direct sunlight, with the cap closed. It has a long shelf life, which is part of why a single bottle lasts most pets many months.

If you mix a diluted topical solution, make it in small batches with purified water and use it within a couple of weeks.

Absolutely — Ox-E is the cleanliness layer that plays well with everything. Long-time families pair it with Black Leaf (the original Immune Boost Bundle), Tracite Minerals (cellular renewal), Bac-Pak Plus (gut balance), and the Antioxidant Treats daily regimen.

For topical needs without the mixing step, Ox-E Mineral Mist is the pre-diluted Ox-E sibling — fortified with zinc, copper, and colloidal silver. Many families keep both: the Drops for internal use, the Mist for the topical playbook.

Our free 30-minute consult is built for exactly this kind of "what should I layer?" question.

Safety & what to expect

No — always dilute Ox-E Drops before use. This is the full-strength concentrate, naturally alkaline at pH 13. Used straight, it can irritate or burn skin, eyes, and ears, and it may stain fabric.

Internal use: add the per-weight drop count to food or water (don't give the concentrate directly by mouth). Topical use: mix a 2% solution first — 1 teaspoon Ox-E to 8 oz purified water — then apply. If undiluted concentrate ever touches skin or eyes, flush thoroughly with water; if it is ever swallowed in concentrated form, give your pet 8 to 16 oz of water.

The upside of that strength: a few drops go a long way, so one diluted bottle lasts most pets many months. Prefer to skip the mixing step for topical care? Ox-E Mineral Mist is the pre-diluted, ready-to-spray sibling.

Yes — Ox-E Drops are safe for dogs and cats of all ages and sizes when used as directed. Because they're highly concentrated, always dilute as directed for topical use and follow the per-weight count for internal use. Just a few drops go a long way.

If your pet has a chronic condition or is on medication, please book a consult first.

Yes. Ox-E Drops are safe for dogs and cats of all ages and sizes when used as directed, and customers have long used them with horses, birds, and other companion animals too.

The rule is the same for every species: dilute for topical use, and follow the per-weight count internally. If an animal has a chronic condition or is on medication, check with your veterinarian or book a consult first.

It varies by pet and by what you're working on. For everyday skin and itch, many owners report a change within the first week or two, and some notice a little more pep within days.

pH balance and immune support build gradually, over weeks rather than overnight, which is why we built in a long 120-day window on purpose. If you're not sure how to read your pet's progress, book a free consult and we'll help you track it.

Choosing, ordering & our guarantee

Auto-ship sends your order on a schedule you choose. You save 10% on every order, always — stacked on top of any quantity discount. Because a single 2 oz bottle lasts most pets 6–12+ months, the cadence options run long — every 6, 9, or 12 months is typical. Pause, change, or cancel anytime from your account.

Ox-E Drops is covered by our 120 Day Worry-Free Guarantee. Try it with your pet for up to four months — if it isn't the right fit, return the unused portion for a full refund. No questions asked, no return-shipping hoops.

That window is intentionally long: pH balance and immune support build over weeks, not days, and we'd rather you have time to see the effect than rush to a verdict. If you're not sure how to evaluate progress, book a consult and we'll help you read what's changing.

Not sure where to start?

Find your dog's formula.

Answer a few questions and we'll point you to the right starting place — or talk to a member of our team. No guessing, no pressure.

Ox-E Drops · 2 oz
1 bottle · One-time · $29.99/bottle
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