Nzymes Skin Rescue Shampoo — gentle natural relief for itchy, irritated skin
Skin Care Only at Nzymes

Skin Rescue Shampoo

4.6 ★★★★★ 112 verified reviews

The scratching has a root. So does the relief.

Most pet shampoos clean the coat and call it done. Skin Rescue is plant-based and enzymatic, made with cold-pressed plant oils and botanicals to calm the skin underneath, where the itch actually starts.

Size 8 fl oz
Purchase type
Ships every
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1 bottle × $24.99$24.99
Order total$24.99
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120 Day Worry-Free Guarantee

Most families notice softer coat & less scratching after the first bath.

Plant-based
Enzymatic formula
Cold-pressed plant oils
Botanicals, not harsh detergents
Made in U.S.A.
Family-owned since 1999
Dogs · Cats · Companions
Gentle enough for all ages
120 Day
Worry-Free Guarantee
Free shipping
On orders $65+
A soapy, tail-wagging dog mid-bath — bath day working for the skin instead of against it

Bath day,
finally on your dog's side.

Real relief starts underneath the skin. Here's what bath day can do while the root cause is being addressed.

Build the bath plan →
  1. 1

    The skin shows the struggle first

    When something is off inside, the skin is often the first place it shows: itch, odor, a greasy coat, endless scratching.

  2. 2

    Harsh baths add insult

    Stripping shampoos dry out and irritate skin that's already struggling.

  3. 3

    The itch cycle feeds itself

    Scratch, irritate, scratch again; the skin never gets a chance to settle.

  4. 4

    Bath day becomes relief

    Plant-based enzymatic cleansing calms the skin underneath the coat instead of stripping it, and the itch loses its fuel while the inside products work the root.

In their own words

What families notice first.

We let the reviews speak for the bath. These are the themes that come up again and again across verified Skin Rescue reviews, starting with the ones we hear most.

4.6★
Average rating
91%
Rated 4 or 5 stars
112
Verified reviews
Most-mentioned result

Calmer, softer skin after bath day is what families mention most.

“This shampoo is the only one we’ve found that soothes her itch and eases the irritation without drying her skin.” · Kristen D., verified review

Calmer, softer skin

"It eased my dog's discomfort and made his skin so much smoother and softer."Michelle D. · Verified review

A softer, shinier coat

"Leaves their coats soft, easy to groom and smells nice and clean."Dee P. · Verified review

Relief from the itch

"Only thing that keeps his skin comfortable, no itching! The only thing I will put on my dog."Stephanie M. · Verified review

A fresh, clean smell

"Gives his hair a great shine and his skin doesn't have a bad odor and feels soft, not dry."Elnor B. · Verified review

Comfort through a yeast detox

"Seems to reduce the itching and discomfort from the yeast on my dog's skin while detoxing."Kathi T. · Verified review

When families tend to notice
The first bathA softer coat and a fresh, clean smell are the changes families report right away
During a flare or detoxBetween-bath comfort on the outside while the inside products work the root
On the shelfIt becomes the bottle families come back to, bath after bath

"Had so much success with Nzymes with my late bulldog, so I called and they walked me right through what to do. The shampoo is great! I would trust Nzymes any day, any time."Rose A. · Verified review

Bar lengths reflect how often each theme is mentioned across verified reviews, not a guaranteed result. Skin Rescue Shampoo is topical care and comfort; it soothes the outside while the root cause is addressed from the inside. Every pet is different and individual results may vary.

Verified customer reviews

How the Skin Rescue Shampoo works

Lift. Calm. Lock.

Three jobs, in order: lift the irritants off the coat, calm the skin underneath, and lock the moisture back in. That's why the itch settles down, not just the smell.

One bath. Three jobs.
01
On the surface

Lift

Dander, dust, dried saliva, and yeast-tinged oils leave with the rinse instead of settling back into the skin.

02
Under the skin

Calm

Black cumin and cooling botanicals go to work on the irritation itself, so the bath soothes instead of stings.

03
Below the skin

Lock

Cold-pressed plant oils seal moisture in. The coat comes out soft, and the skin doesn't feel stripped and dry.

Inside the bottle

Key ingredients.

Every ingredient earns its place — no sulfates, no parabens, no synthetic fragrance, no dyes.

Cold-pressed coconut oil — gentle cleanser in Nzymes Skin Rescue Shampoo

Cold-pressed coconut oil

The cleanser: gentle enough for kittens, strong enough for senior shepherds.

Read the science

The scienceCoconut-derived fatty-acid surfactants do the lifting work, binding to dander, dust, dried saliva, and the yeast-tinged oils that build up on the coat, without stripping the skin's own protective layer the way harsher sulfate cleansers do.

What it meansThis is why the shampoo can be used as often as your pet needs it without making the skin worse. Effective enough to clean, gentle enough to repeat.

Black cumin seeds — key ingredient in Nzymes Skin Rescue Shampoo

Black cumin oil

The calmer: the most studied botanical in the bottle, and its steadiest worker.

Read the science

The scienceBlack cumin oil (Nigella sativa) carries thymoquinone, a naturally occurring compound long studied for its role in supporting skin comfort and a balanced surface microbiome. It's cold-pressed so the active compounds stay intact.

What it meansThis is the ingredient families point to when they tell us the scratching finally slowed down. Quiet, steady work, bath after bath.

Fresh spearmint leaves — cooling botanical in Nzymes Skin Rescue Shampoo

Spearmint + botanicals

The cooling layer: spearmint, peppermint, thyme, rosemary, and clove together.

Read the science

The scienceA blend of plant essential oils: spearmint and peppermint for cooling, rosemary and thyme for surface freshness, and clove for its long history in soothing washes. All cold-pressed or steam-distilled, with no synthetic fragrance.

What it meansThis is why the bath smells clean instead of perfumed or medicinal, and why it feels cooling on irritated spots.

Cold-pressed almond oil — moisturizing layer in Nzymes Skin Rescue Shampoo

Almond oil + cold-pressed allies

The conditioner: cold-pressed almond, olive, and avocado oils in one rinse.

Read the science

The scienceCold-pressed plant oils carry the fatty acids skin already uses to maintain its own moisture barrier. Almond contributes vitamin E, olive brings oleic acid, and avocado adds heavier lipids, so the trio conditions during the rinse with no separate conditioner needed.

What it meansDry, flaky "elephant" skin softens, and the coat comes out nourished rather than slicked over with synthetic conditioner.

No sulfates. No parabens. No synthetic fragrance. No dyes. Cold-pressed plant oils & botanicals only.

Bath ritual

How to use.

A full bath or a spot wash — same simple sequence, every time.

01

Wet the coat

Warm water, all the way through to the skin. A thin line of shampoo along the top line goes a long way; Skin Rescue is concentrated.

02

Massage & soak

Work it into the skin and coat. Let it sit for 4–5 minutes — that's the part most people skip, and it's when the botanicals do their work.

03

Rinse & repeat as needed

Rinse thoroughly. For a stubborn case or a particularly dirty pet, lather and rinse a second time; it's gentle enough for repeated use.

Safe for full baths or spot washes. Use it directly on a hot spot or itchy patch between baths.

Find your bathing schedule

How often should we bathe?

Pick the situation. We'll suggest a cadence — and how long one bottle lasts.

Tell us about your pet

What's going on right now?

Pick a situation to see the recommended cadence — and how long one bottle lasts.
Recommended cadence
Weekly maintenance
1 bath per week
One 8 fl oz bottle lasts ~3 months

Auto-ship 1 bottle every 3 months keeps your pet stocked — and saves 10% on every order.

We originally formulated Skin Rescue for the chronic-yeast cases that brought customers to Nzymes in the first place. What we learned along the way: a shampoo strong enough for the hardest skin conditions can still be gentle enough for every bath.

The bath and the spray

Which skin care fits the situation?

Two forms of relief for the outside: the shampoo works on bath day, the spray works between baths. Here's how to tell which one the moment calls for.

The bath and the spray, side by side.
Skin Rescue Shampoo
Skin Rescue Shampoo
$24.99 · 8 fl oz
Ox-E Mineral Mist
Ox-E Mineral Mist
$14.99 · 4 fl oz spray
Format
Concentrated bath shampoo — full-body cleanse + soothe
Fine-mist spray — leave-on, no rinse, anywhere on the body
What it does
Lifts irritants, calms the skin, locks in moisture during the bath
Daily mineral support — skin, ears, eyes, oral
Best for
Yeasty, itchy, smelly, or flaky coats — anything that needs a full-body reset
Hot spots, sensitive ears, raw patches — daily touch-ups between baths
Cadence
1–2 baths/week during a flare, weekly for maintenance
As needed — daily on a hot spot is fine
Safe for
Dogs, cats & companion animals — all ages
Pets AND people
Pairs with
Mineral Mist between baths · internal foundation (Treats/Granules)
Skin Rescue Shampoo on bath day · Ox-E Drops in food & water
What pairs with the shampoo

The shampoo calms the outside. Nzymes calms the inside.

Pair Skin Rescue Shampoo with Mineral Mist between baths, plus Antioxidant Treats or Sprouted Granules in the bowl, and you've got the whole inside-out system working at once.

A happy French bulldog grinning up from a bubble bath — the everyday relief Skin Rescue is built for

Relief you can see.
Comfort they can feel.

Even for the toughest skin problems.

Nzymes was built on the hard cases nobody else would touch. Chronic yeast, raw hot spots, coats that never seemed to recover between flares: those are the dogs that brought families to us, and this shampoo was formulated for them. We believe relief should never come at the skin's expense, so every wash is plant-based, enzymatic, and gentle enough to repeat as often as your dog needs. And if you're not sure bath day is enough, call us. We'll walk you through it, the same way we have with families since 1999, and the consult is free.

FAQs

Common questions.

Understanding the shampoo

Skin Rescue Shampoo is built for pets dealing with itchy, irritated, yeasty, or flaky skin — and for any pet whose coat needs a gentle, no-fuss bath. It lifts the irritants off the coat, calms the skin underneath with cold-pressed botanicals, and locks moisture back in. Most pet parents notice softer coat and less scratching after the first bath.

Bath day, day to day

For an active flare — scratching, odor, hot spots — bathe 1–2 times per week until things settle, then back off to weekly. For a healthy coat, once a week is plenty. The shampoo is gentle enough that "too often" isn't really a risk.

Need a personal plan? Use the Bath Plan tool above — it'll suggest a cadence based on what's going on with your pet right now.

Yes. Skin Rescue is formulated for dogs, cats, and companion animals — kittens through seniors. It's free of sulfates, parabens, synthetic fragrance, and dyes. The same bottle works on a Great Dane and a kitten because we built it around cold-pressed plant oils and botanicals — not harsh cleansers that strip the coat.

One note for cat parents: cats are sensitive to certain essential oils. Skin Rescue uses low concentrations specifically chosen to be safe for cats, but if your cat has a chronic condition, book a consult and we'll talk through it.

Here's the honest answer: yeast issues almost always start in the gut, not on the skin. The shampoo will lift the surface yeast, calm the irritation, and dial back the smell — and most families notice that within the first few baths.

But if the imbalance is chronic, the bath alone isn't enough. For chronic yeast we recommend our Skin Rescue Bundle — or book a consult first so we can talk through whether the bundle is right for your pet.

In: cold-pressed plant oils (almond, olive, avocado, coconut, sesame), botanical essential oils (black cumin, spearmint, peppermint, rosemary, thyme, clove), aloe vera leaf juice, fern extract, vitamin E, and gentle coconut-derived surfactants.

Not in: sulfates (no SLS/SLES), parabens, synthetic fragrance, artificial dyes, phthalates, or harsh detergents.

Different jobs. The shampoo is the full-body bath — lather, soak, rinse — for whole-coat itch, odor, and flaky skin. Mineral Mist is a fine-mist spray you can use daily on hot spots, sensitive ears, or anywhere a quick touch-up helps. They pair naturally: bath day with Skin Rescue, between-bath touch-ups with Mineral Mist.

If you want the full picture, the Three ways to soothe comparison above walks through all three external options side-by-side.

Ordering & guarantee

Auto-ship sends your order on the cadence you pick — monthly, every 2 months, up to every 6 months. You save 10% on every order, stacked on top of any quantity discount. No commitment — pause, change, or cancel anytime from your account.

Skin Rescue is covered by our 120 Day Worry-Free Guarantee. Use the bottle with your pet for up to four months — if you don't see softer coat and calmer skin, return the unused portion for a full refund. Most families notice changes after the first bath; the longer guarantee window exists because skin issues sometimes need pairing with the internal foundation to fully settle, and we want you to have time to figure that out.

Not sure where to start?

Find your dog's formula.

Answer a few questions and we'll point you to the right starting place — or talk to a member of our team.
No guessing, no pressure.

Skin Rescue Shampoo
1 bottle · One-time · $24.99/bottle
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